Tooth decay (dental caries) is a major global public health problem and according to the WHO is the most widespread non-transmissible disease in the world. Transillumination with near-infrared light imaging (TI) has been shown to be effective in the vital early detection of tooth decay. Applying translational research and technology, scientists from the EPFL Blue Brain Project and the University of Geneva have collaborated to develop a new deep learning model for the automated detection and localization of dental lesions in TI images.