For the first time, scientists at the EPFL Blue Brain Project, a Swiss brain research initiative, have extended performance modelling techniques to the field of computational brain science resulting in findings that are useful for today and indispensable for the future. In a paper published in Neuroinformatics, they provide a quantitative appraisal of the performance landscape of brain tissue simulations, and analyze in detail the relationship between an in silico experiment, the underlying neuron and connectivity model, the simulation algorithm and the hardware platform being used. Thereby deriving the first analytical performance models of detailed brain tissue simulations, which is a concrete step to enable the next generation of brain tissue simulations.