Blue Brain Portal

Welcome to the Blue Brain Portal – a knowledge space for simulation neuroscience

Models

Multi-scale models of the rat and mouse brain integrate models of ion channels, single cells, microcircuits, brain regions, and brain systems at different levels of granularity (molecular models, morphologically detailed cellular models, and abstracted point neuron models).

Online Tools

The online tools available to assist users with simulation neuroscience are a collection of platforms and atlases from the Blue Brain and our collaborators.

Online Learning

Simulation Neuroscience is an emerging approach to integrate the knowledge dispersed throughout the field of neuroscience.

Software

Blue Brain’s reconstruction and related simulations are made possible by a comprehensive software ecosystem for each step in the reconstruction and simulation process. Blue Brain systematically releases open source software.

Data

Data is of vital importance to the study of the Brain. For neuroscientists in this section, there are ion channel recordings, morphological reconstructions, electrical recordings from neocorticol neurons and molecular properties of neurons. These are available on Blue Brain platforms, the EBRAINS Cellular Level Simulation Platform and the Hippocampus Hub.

Publications

Blue Brain has published more than 195 papers and pre-prints.

News and Announcements

The Blue Brain Project News

A machine reveals how glucose helps the SARS-CoV-2 virus

— Why do some people get sick and die from COVID-19 while others seem to be completely unaffected?EPFL’s Blue Brain Project deployed its powerful brain simulation technology and expertise in cellular and molecular biology to try and answer this question. A group in the Blue Brain assembled an AI tool that could read hundreds of thousands of scientific papers, extract the knowledge and assemble the answer – A machine-generated view of the role of Blood Glucose Levels in the severity of COVID-19 was published today by Frontiers in Public Health.

What do we know about the rodent thalamocortical circuitry?

— The Blue Brain Project follows a four-year roadmap with specific scientific milestones to achieve its ultimate goal, digitally reconstructing and simulating the entire mouse brain. One of the goals in the current period is to model structures with direct relevance for the neocortex. The thalamus is highly interconnected with the cortex and plays an important role in an array of cognitive processes. It funnels sensory input to the neocortex with the thalamocortical loop playing a central role in cerebral rhythmogenesis (biological rhythm). As such, it has a key role in many functions, such as sleep and wakefulness and is involved in various diseases associated with dysfunction of rhythmic activity such as epilepsy, autism, schizophrenia and bipolar disorder. However, there is much that scientists do not know about this brain region and as the understanding of the thalamocortical system deepens, so does the complexity of the questions scientists face.

All news