In the Spring of 2022, the EPFL Blue Brain Project announced in a paper published in Cell Reports that it had found a way to mathematically build the 3D tree-like geometries of neurons using algebraic topology. One of the main branches of pure mathematics, algebraic topology allowed Blue Brain to describe the geometrical shapes of neurons in a way that could be used to build their digital twins. This breakthrough opens the path to using computers to automatically build digital copies of any of the thousands of different types of neurons found in the brain. The study, led by Blue Brain’s Neuromathematics Leader Lida Kanari and EPFL Professor Kathryn Hess of the Laboratory for Topology and Neuroscience, was the latest in a series of Blue Brain studies where algebraic topology helped tackle and solve a wide range of previously intractable neuroscience problems.