Living with the effects of the SARS-CoV-2 virus (COVID-19) for nearly two years, we have all come to understand the importance and role of diagnostic testing in responding effectively to the immense threat of COVID-19. Back in early 2020, the EPFL Blue Brain Project and FIND, the global alliance for diagnostics, collaborated to develop a Diagnostic Implementation Simulator for SARS-CoV-2 diagnostics, which uses modelling data to simulate scenarios and estimate the potential impact of deploying different testing strategies for COVID-19. The collaboration has today released an updated version of the Simulator, which has evolved to keep pace with the specific needs of COVID-19 and address public health requirements. The Simulator is now capable of modelling specific testing scenarios and multiple pandemic phases.