Multi-scale models of the rat and mouse brain integrate models of ion channels, single cells, microcircuits, brain regions, and brain systems at different levels of granularity (molecular models, morphologically detailed cellular models, and abstracted point neuron models).
Blue Brain’s reconstruction and related simulations are made possible by a comprehensive software ecosystem for each step in the reconstruction and simulation process. Blue Brain systematically releases open source software.
The online tools available to assist users with simulation neuroscience are a collection of platforms and atlases from the Blue Brain and our collaborators.
Data is of vital importance to the study of the Brain. For neuroscientists in this section, there are ion channel recordings, morphological reconstructions, electrical recordings from neocorticol neurons and molecular properties of neurons. These are available on Blue Brain platforms and the Human Brain Project Brain Simulation platform.
Tooth decay (dental caries) is a major global public health problem and according to the WHO is the most widespread non-transmissible disease in the world. Transillumination with near-infrared light imaging (TI) has been shown to be effective in the vital early detection of tooth decay. Applying translational research and technology, scientists from the EPFL Blue Brain Project and the University of Geneva have collaborated to develop a new deep learning model for the automated detection and localization of dental lesions in TI images.
Researchers at EPFL’s Blue Brain Project, a Swiss brain research Initiative have combined two high profile, large-scale datasets to produce something completely new – a first draft model of the rules guiding neuron-to-neuron connectivity of a whole mouse neocortex. Based on these rules, they were able to generate statistical instances of the micro-connectome of 10 million neurons, a model spanning five orders of magnitude and containing 88 billion synaptic connections that will serve as the basis of the world’s largest-scale simulations of detailed neural circuits.