Blue Brain’s reconstruction and related simulations are made possible by a comprehensive software ecosystem for each step in the reconstruction and simulation process. Blue Brain systematically releases open source software.


Neuroinformatics is concerned with organizing neuroscience data and providing tools to facilitate the analysis of this data. Neuroinformatics is an essential aspect of Blue Brain’s methodology and provides a fundamental data management structure and set of activities by which Blue Brain operates. Blue Brain Nexus has been built by the Blue Brain Project to organize, store and process exceptionally large volumes of data and support usage by a broad number of users.

In silico Experiment

In order to improve performance and benefit from new computing architectures, the core functionalities of the widely used NEURON simulator have been isolated and optimized into a new simulator CoreNEURON. This software tool helps existing NEURON users to simulate their models faster, better utilizes computing resources and helps to deliver science early. This software tool is developed in collaboration with Michael Hines at Yale University.


Blue Brain has developed a state-of-the-art modular visualization architecture for large data visualization over a wide range of use cases to deliver an unprecedented capability of viewing, analyzing, validating, troubleshooting and communicating neuroscientific structures and functions.


Blue Brain building tools aim to build comprehensive digital reconstructions of brain structures at different levels of organization that are compatible with the available experimental data. The strategy of these tools is to identify interdependencies in the experimental data and use them to constrain the reconstruction process. Blue Brain software applications are customizable to be reusable for various brain regions for the benefit of the community.


Within Blue Brain’s workflow is the analysis of simulation results. The analysis stage is initially for model validation and then subsequently for simulation-based investigations of brain function and dysfunction, diagnostic tools and possible treatments.  The analysis step of Blue Brain’s workflow is supported by two open source software tools – the Electrophysiology Feature Extraction Library (eFEL) and NeuroM.